Abstract
ABSTRACT: BACKGROUND: Alpha1-adrenoceptor blocking agents showed several effects beyond their action on the vascular smooth muscles. They improve the lipid profile and inhibit the aggregation of blood platelets. OBJECTIVE: To investigate the clot-lysis effect of selective α1-adrenoceptor antagonists and its relation to peroxynitrite level in vitro experimental model. MATERIALS AND METHODS: Venous blood samples obtained from ten healthy subjects. To each pre-weighed clot, 100 μL of either distilled water as a negative control, prazosin (10 μg), terazosin (20 μg) and alfuzosin (25 μg) were added. Peroxynitrite level was measured in sera and sangious fluid that formed after clot-lysis. RESULTS: Prazosin, terazosin and alfuzosin,in order, significantly reduced the clot weight up to 3.7%. Peroxynitrite level in sangious fluids was higher in treated groups than that of negative control or sera levels. CONCLUSION: α1-adrenoceptor antagonists induced clot-lysis effect. This effect is associated with generation peroxynitrite
Recommended Citation
Al-Nimer, Marwan S.M.; AL-Gareeb, Ali Ismail A.; and Al-Kuraishy, Hayder M.
(2011)
"The Clot-lysis Effect of Selective α1-Adrenoceptor Antagonist in Vitro Model Associated with High Peroxynitrite Level,"
Iraqi Postgraduate Medical Journal: Vol. 10:
Iss.
2, Article 23.
Available at:
https://ipmj.researchcommons.org/journal/vol10/iss2/23