Immunohistochemical Expression of Matrix Metalloproteinase-9 in Jaws and Long Bones Osteosarcomas

Authors

• Bashar Hamid Abdullah
• Luay Edward Alkhuri
• Khitam Razzak Alkhafaji
• Salam Nihad Jawad

Abstract

ABSTRACT: BACKGROUND: Matrixmetalloproteinases (MMPs) are a class of matrix basement membrane degrading enzymes which were shown to be associated with metastases in several human tumors. OBJECTIVE: This study is aimed to investigate the potential effect of MMP-9 in imparting the frequently reported different behavioral pattern between jaws and long bones osteosarcomas. METHODS: Tissue blocks of ten cases of jaws osteosarcomas and another ten of long bones osteosarcomas were collected and stained immunohistochemically with monoclonal antibodies to MMP-9. RESULTS: The majority of cases (70%) were positive for MMP-9 expression which indicates a role in tumor spread, however; there was no significant difference between the sites. CONCLUSION: The study indicates that MMP-9 is probably not involved in the biologic differences between jaws and long bones osteosarcomas

Recommended Citation

Abdullah, Bashar Hamid; Alkhuri, Luay Edward; Alkhafaji, Khitam Razzak; and Jawad, Salam Nihad (2011) "Immunohistochemical Expression of Matrix Metalloproteinase-9 in Jaws and Long Bones Osteosarcomas," Iraqi Postgraduate Medical Journal: Vol. 10: Iss. 3, Article 20.
Available at: https://ipmj.researchcommons.org/journal/vol10/iss3/20