Abstract
ABSTRACT: BACKGROUND : p53 gene is the most common mutation in human cancers.In bladder cancer, p53 mutations have been associated with high tumor grades and advanced stages.Moreover,p53 nuclear over expression appears to be an independent predictor of disease progression and decreased survival after cystectomy. OBJECTIVE: To identify the role of p53 nuclear protein in prediction the progression and recurrence of superficial tumor of the bladder in response to intravesical chemotherapy PATIENTS AND METHOD : The expression of p53 protien was studied by immunohistochemical analysis from 71 patients with superficial tumor bladder and all of them were treated by intravesical chemotherapy followed periodically every three months by cystoscopy RESULT : P53 over expression was observed in 38out of 71(54%) patients with superficial tumor of the bladder. A statisticaly significant relation was noticed between P53 over expression and tumor grades , however statistical significant relation between p53 negative expression and response to intravesical mitomycin C chemotherapy was noticed , moreover , patients who received intravesical mitomycin C chemotherapy , 71% showed response with in 3 month , while 29% showed recurrence . Moreover, it seems that P53 status did predict response to intravesical mitomycin C chemotherapy. CONCLUSION : The response of intravesical chemotherapy in patients with superficial transitional cell carcinoma was higher in p53 negative expression.
Recommended Citation
Nima, Montadhar Hameed and Azeez, Rasha Abbas
(2011)
"The Role of P53 nuclear Protein in Prediction of Progression and Recurrence of Superficial Tumor of the Bladder in Response to Intravesical Chemotherapy,"
Iraqi Postgraduate Medical Journal: Vol. 10:
Iss.
4, Article 17.
Available at:
https://ipmj.researchcommons.org/journal/vol10/iss4/17