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Abstract

ABSTRACT : BACKGROUND: Helicobacter pylori is recognized as an important human pathogen by virtue of its association with peptic ulcer disease , gastric cancer , gastric lymphoma and high prevalence of infection worldwide. Recently this organism was detected in tonsil and adenoid tissue after adenotonsillectomy , as well as in mucosa of patients with chronic rhinosinusitis , but its association with simple nasal polyposis has not been investigated yet in our country . OBJECTIVE: To investigate a possible contribution of Helicobacter pylori (H.pylori) in the etiopathogenesis of simple nasal polyps . Study Design: Prospective clinico –pathological investigation. METHODS : Twenty eight patients with nasal polyposis were studied for the presence of Helicobacter pylori in the nasal polyp specimens by histopathological examination of serial sections stained by modified Giemsa stain . RESULTS: Helicobacter pylori was detected in 10 (35%) of total 28 simple nasal polyps specimens. CONCLUSION: This study found a significant percentage 10/28 patients (35%) with Helicobacter pylori infection in nasal polyps and to confirm the role of Helicobacter pylori in the etiopathogenesis of nasal polyposis , extensive epidemiological studies would be necessary

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