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Abstract

ABSTRACT: BACKGROUND: Psoriasis is a common chronic condition of the skin that is resistant to many therapies. There is a need for the development of novel non-steroidal topical drugs for the treatment of psoriasis. OBJECTIVE: To assess the efficacy and safety of topical podophyllin 5% ointment in patients with mild plaque- type psoriasis. PATIENTS AND METHODS: Sixty two patients with mild plaque-type psoriasis were enrolled in this study. They were divided into 3 groups: GroupA (21patients)were treated with podophyllin 5% ointment every other day, while Group B(20patients)were treated with clobetasol propionate 0.05%ointment twice daily and 21 patients in Group C were treated with Vaseline twice daily for 8 weeks as a control group. Efficacy was evaluated every 2 weeks for 8weeks using Psoriasis Area and Severity Index (PASI) score and relapse was recorded after cessation of treatment in those patients who achieved good response during 8 weeks follow up period. RESULTS: A total of 62patients were 44(70.9%) males and 18(29.0%) females, with: male: female ratio 2.3:1. Their ages ranged from 18-65 (37.5±12.9) years. Their baseline PASI score ranged from 1.29(5.2±2.4). At the end of 8 weeks of therapy : no statistically significant difference in PASI reduction between Group A(66.3±20.7) and Group B(68.1±34.2) treated patients, P-value =0.831 and both of them were statistically significant higher PASI reduction than patients with Group C,34.1±28.8, P-value =

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