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Abstract

ABSTRACT: BACKGROUND: CA-125 is a glycoprotein, its origin is uncertain during pregnancy. It rises during the first trimester and returns to a non-pregnancy range in late pregnancy. OBJECTIVE: To compare CA-125 levels between tubal ectopic and normal intrauterine pregnancy, and to find it’s usefulness in differentiating intact from ruptured tubal ectopic pregnancy. METHODS: This prospective case-control study was carried out on sixty healthy women with single normal intrauterine pregnancy (NIUP) of 6-10 weeks gestation and sixty women with tubal ectopic pregnancy of same gestational age which were further subdivided into twenty-five women with ruptured tubal ectopic pregnancy (REP) and thirty-five women with unruptured tubal ectopic pregnancy (UREP). The levels of CA-125 were compared between these groups. RESULTS: The mean level of CA-125 in ruptured ectopic pregnancy group was 49.04±33.63 IU/ml and in unruptured ectopic pregnancy group was 24.3±16.89 IU/ml. The mean level of CA-125 in normal pregnant women (control group) was 53.95±31.2 IU/ml. There was a statistically significant difference between mean serum CA-125 levels of ruptured ectopic pregnancy and unruptured ectopic pregnancy group (p< 0.05), also there was a statistically significant difference between mean of CA-125 level of unruptured ectopic pregnancy group and control group (p 0.05). CONCLUSION: CA-125 level is significantly elevated in ruptured tubal ectopic pregnancy than the intact tubal ectopic pregnancy, this increase in CA-125 levels can be used as additional test to identify tubal rupture

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