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Abstract

ABSTRACT: BACKGROUND: Type 1 diabetes mellitus is a chronic autoimmune disease that involves destruction of the pancreatic beta cells. It is well known that both genetic and environmental factors involved in pathogenesis of type-1diabetes mellitus. OBJECTIVE: This study seeks to determine whether there is any association between human leukocyte antigen class I and II alleles and type-1diabetes mellitus. SUBJECTS AND METHODS: Seventy type-1 diabetes mellitus patients compared to 30 apparently healthy individual were enrolled in this study. Human leukocyte antigens genotyping were analyzed by polymerase chain reaction sequence specific oligonucleotide technique. RESULTS: The present study revealed significantly high frequency of DQB1*0101 and DQB1*0201 alleles among patients in comparison with healthy control, while there was significantly low frequency of each HLA-A*3301, B*0826, DRB1*0701, *1101 and HLA-DQB1*0604 alleles in patients as compared to healthy controls. CONCLUSION: These findings indicate that higher frequency of HLA-DQB1*0101 and *0201 alleles may be a risk factor for type-1diabetes mellitus, meanwhile low frequency of HLA-A*3301, B*0826, DRB1*0701, *1101 and HLA-DQB1-*0604 alleles could be a protective factor.

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