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Abstract

ABSTRACT: BACK GROUND: Fever may be the only indication of a severe infection, it occurs in about (10 -50%) of patients with solid malignancy during chemotherapy-induced neutropenia. OBJECTIVE: To determine the common pathogens causing febrile neutropenia and their susceptibility to antibiotics in patients with solid malignancies in oncology teaching hospital. PATIENTS AND METHODS: 50 patients with solid malignancy were enrolled in this cross sectional study. Blood culture and sensitivity test were investigated for them. Other sample cultures were investigated according to system involvement. RESULTS: Blood culture was positive in 18% of patients. Gram negative bacteria were predominant (81.81%). Among which E.coli being the most common (33.33%). E.coli was the isolate in the only 2 (4%) positive Urine culture. The most frequently effective antibiotic for Gram negative infections was Amikacin followed by Imipenem compared to Ciprofloxacin, Tetracycline and Aztreonam for Gram positive ones. CONCLUSION: Gram negative bacteria were the most bacteria isolated in the studied patients.

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