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Abstract

ABSTRACT : BACKGROUND: GGT ( gamma- glutamyl transferase ) enzyme is found on the surface of various cells and plays a role in the catabolism of glutathione which is known as one of the major anti oxidants, OBJECTIVE: Of this study : was to emphasize the changed GGT values as anew biochemical marker for acute coronary syndrome METHOD: Type of study is a case – control study. The study population: We enrolled 50 patients with acute coronary syndrome who had been admitted to ccu unit in Merjan Teaching hospital, measurement of serum gamma- glutamyl transferase level using gamma- glutamyl transferase was measured by enzymatic method using the Abbott Architect C16000 autoanalyser and compared to the serum gamma- glutamyl transferase level of the 50 control group , the period of the study is 6 months. Both groups will under go an exclusion criteria for all causes that may lead to a high gammaglutamyl transferase level mainly hepatobiliary diseases , alcohol history, diabetes mellitus , and drugs that affect the gamma- glutamyl transferase level . RESULT: Of the study: showed that gamma- glutamyl transferase level is elevated in all patients with documented acute coronary syndrome after exclusion of other factors which cause elevation of gamma- glutamyl transferase in comparism with the control . CONCLUSION & RECOMMENDATION: This study depicts association of gamma- glutamyl transferase with acute coronary syndrome in population from Babylon governorate & Larger community based studies are needed to establish the role of gamma- glutamyl transferase in development of the commonly mentioned risk factors of acute coronary syndrome. We recommend the use of GGT as a biomarker within the 4 days events of acute coronary syndrome .

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