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Abstract

BACKGROUND: Pneumoperitoneum with CO2 insufflation is used during laparoscopic cholecystectomy to facilitate surgical access as it is a minimally invasive procedure, and despite its benefits when compared to the open cholecystectomy, it is known that pneumoperitoneum has some adverse physiological effects including an abrupt increase in the arterial blood pressure and an increase in the heart rate due to increased catecholamines release. OBJECTIVE: To investigate the effect of magnesium sulfate on attenuating the hemodynamic response to carbon dioxide pneumoperitoneum in patients undergoing laparoscopic cholecystectomy. PATIENTS AND METHODS: This double blind prospective study was conducted in Rizgari Teaching Hospital in Erbil/Iraq on 60 patients whose ages ranges between (20-45) years to assess the effectiveness of magnesium sulfate in attenuating the hemodynamic response to cholecystectomy, after dividing the patients into two groups: group I (magnesium group) and group II control group. RESULTS: The increase in systolic blood pressure, diastolic blood pressure, mean arterial blood pressure and heart rate readings were less in group I (Magnesium group) when compared to group II (control group) with a statistically significant difference (p < 0.05). CONCLUSION: It can be concluded that magnesium sulfate attenuates the hemodynamic response to pneumoperitoneum in laparoscopic cholecystectomy. KEYWORDS: Magnesium sulfate, Laparoscopic cholecystectomy,

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