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Abstract

BACKGROUND: Osteoarthritis is a low-grade systemic inflammatory and degenerative disease in which many inflammatory mediators are known to be elevated in the peripheral blood. Platelet lymphocyte ratio and neutrophil monocyte ratio are novel markers in many systemic inflammatory disorders. Studies are limited on its link with knee osteoarthritis severity.  OBJECTIVE: To evaluate the relationship of  PLR  and NMR  with the Knee Osteoarthritis (KOA) severity PATIENTS AND METHODS: A total of 200 patients with KOA were diagnosed according to the American College of Rheumatology clinical criteria 2016.  Demographic and clinical characteristics data were recorded.  X-ray was taken for both knee joints in standing and lateral position view.   Blood samples were collected PLR and NMR were calculated. RESULTS: Mean age was 62.3 ± 8.7 years, female to male ratio as 1.5:1. Mean BMI was 29.2 ± 6.3 kg/m2, and knee OA duration  9.8 ± 7.8 years.   Age, knee OA duration, menopausal duration, total WOMAC score and menopause were significantly correlated with increase knee OA severity (p<0,001), (p<0,001), (p<0,001), and (p=0,003) respectively while marital status was significantly inversely correlated with knee OA severity (P<0.001).    Knee OA duration and total WOMAC score were the only independent predictors of knee OA severity (p<0.001), (p<0.001) respectively.  PLR and NMR were not correlated with severity of KOA. CONCLUSION: PLR and NMR had no significant correlation with the KOA severity

DOI

10.52573/ipmj.2020.167329

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