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Abstract

BACKGROUND: Although laparoscopic cholecystectomy became the gold standard for the treatment of gallstone disease, there is some risk of surgical site infection that required prophylactic antibiotic. Prophylaxis for low risk patients is still controversial as well as whether single or multiple doses is needed. AIM OF STUDY: Compare between single vs. multiple dose of antibiotic prophylaxis in laparoscopic cholecystectomy in terms of post-operative infection and cost. METHODS: A prospective study conducted at Baghdad Teaching Hospital, from January 2017 to March 2018. 200 patients admitted for elective laparoscopic cholecystectomy randomly divided in two equal groups: single dose (SD) group was given ceftriaxone (2gm) intravenously at induction of anesthesia, and multiple doses (MD) group was given ceftriaxone (2gm) intravenously at induction of anesthesia followed by ceftriaxone (1gm) intravenously twice a day for two days postoperatively. Surgical site infection and treatment cost in two groups compared and analyzed.  RESULTS:  Postoperative infection rate was 1% in both groups; the difference was not significant (p=1).                 The cost was higher in MD group. CONCLUSION: Single dose prophylactic antibiotic administered at induction of anesthesia, is equally effective as multiple doses to prevent post-operative infection in low risk patients undergoing laparoscopic cholecystectomy and is cost effective.  

DOI

10.52573/ipmj.1970.175760

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