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Abstract

BACKGROUND: Betatrophin has been reported to have a role in beta cell talk about insulin resistance states. Betatrophin levels association with gestational diabetes mellitus (GDM) in comparison to normal glucose tolerance need to be evaluated. AIM OF THE STUDY: Assessment of betatrophin level in pregnant women with gestational diabetes in comparison to those with no gestational diabetes. PATIENTS AND METHODS: Case control study .The study included 100 pregnant women divided in to 2 groups. 1st group –included 50 pregnant women diagnosed to have GDM. 2nd group –included 50 pregnant women with no GDM as control group. For all included women measurement of maternal serum betatrophin level was performed. RESULTS: The Mean ±SD of betatrophin in women with GDM was (295.78 pg/ml ±193.03pg/ml) and in control group was (157.04 pg/ml ±77.62pg/ml) it was significantly higher in association with GDM at p value <0.001. In GDM, betatrophin level were significantly correlated with maternal age, parity, HbA1c(r=0.455, p=0.001), (r=0.413, p=0.003), (r=0.287, p=0.044) respectively. No significant correlation with BMI   (r=0.163, p=0.258) nor with gestational age   (r=0.065, p=0.654). ROC curve for betatrophin level as diagnostic aid for GDM demonstrated that AUC was 0.692 at p value 0.001, sensitivity 62.0%, specifity 66.0% cutoff value 185.5 ng/ml. CONCLUSION: Betatrophin is significantly higher in pregnant women who have gestational diabetes in comparison with normal healthy pregnant women and it is significantly correlated with maternal age, parity, and HbA1c.  

DOI

10.52573/ipmj.2023.179298

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