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Abstract

BACKGROUND: Ectopic pregnancy causes major maternal morbidity and mortality. Human Placental growth hormone shows a non-pulsatile secretion pattern and short serum half-life making it of major advantage compared to the standard marker human chorionic gonadotropin. OBJECTIVE: To evaluate the clinical implication of serum human placental growth hormone variant and immunohistochemistry as a possible biomarker for the course of ectopic pregnancy. PATIENTS AND METHODS: This is a cross sectional study carried out in the department of Obstetrics and Gynecology of                        Al- Yarmouk Teaching Hospital for the period from January 2020 to October 2020, It includes 50 pregnant women in first trimester with confirmed ectopic pregnancy, maternal serum β -human chorionic gonadotrophin titer was measured and human placental growth hormone variant level was analyzed for each patient using enzyme-linked immunosorbent assay and tissue specimen were taken from serum human placental growth hormone variant negative and positive cases and examined by immunohistochemistry. RESULTS: Serum human placental growth hormone variant was shown to be positive in 28 cases of ectopic pregnancy and negative in 22 cases, β-human chorionic gonadotropin levels were significantly higher in the serum of the patient with human placental growth hormone variant positive group (p-value = 0.001).  Serum human placental growth hormone variant was positive in all specimens of cases examined by immunohistochemistry even in serum negative cases. CONCLUSION: Human Placental growth hormone was shown to be present both in serum and tissue of ectopic pregnancy patients. Its short half-life makes it of a great clinical advantage as a biomarker for ectopic pregnancy course and monitoring response to treatment.  

DOI

10.52573/ipmj.2023.181196

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