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Abstract

BACKGROUND: Generally, nipple discharge represents a benign etiology. In the case where the discharge is unilateral, uniductal, spontaneous, persistent, serous or bloody, and in the case where it occurs in conjunction with a mass, the risk of malignancy is increased. Ductal ectasia and papilloma are the most common causes of pathological nipple discharges. Malignancy is a possibility, most often ductal carcinoma in situ.OBJECTIVE: To determine the value regarding dynamic contrast improved magnetic resonance imaging (MRI) in diagnosing suspicious nipple discharge.METHOD AND PATIENTS:Dynamic contrast MRI was used to assess 35 patients who have pathological nipple discharges.                    The features of MRI have been studied and associated to the histo-pathology.RESULTS: Histopathology indicated 11 high-risk, 17 benign, and 7 malignant lesions. The presence of non-mass and mass enhancements, as well as T2 weighted MRI images, had statistical significance in distinguishing malignant from benign causes of the pathological nipple discharges (Pvalue=0.004 and0.008) (0.018,0.008,0.004).94.1% specificity and 94.4% sensitivity in distinguishing benign from malignant pathological nipple discharge causes, and 94.3% accuracy in diagnosing breast lesions, with positive predictive value                  of 94.4% as well as a negative predictive value of 94.1%.CONCLUSION: MRI is a powerful technique for determining the cause of pathological nipple discharge. 

DOI

10.52573/ipmj.2023.182296

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