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Abstract

BACKGROUND:In pregnancy, Gestational Diabetes Mellitus is considered as intolerance to carbohydrate which discovered in pregnancy. It is a glucose metabolism abnormality associated with long and short-term morbidities that could affecting both of the offspring and mother such as shoulder dystocia, preeclampsia or hypertension.OBJECTIVE:To evaluate the level of serum adropin in pregnant ladies with Gestational Diabetes Mellitus (GDM) in comparison with that of normal euglycemic pregnant patient.METHODS:At National Diabetes Center and AL-Yarmouk teaching hospital, a case-control study was done for the period from January 2020 to October 2020. Forty pregnant ladies with Gestational Diabetes Mellitus (cases) and fifty healthy pregnant ladies (controls) were involved. Lipid concentration and serum adropin were evaluated between 24th-28th weeks of pregnancy for the two groups. The results were compared between them using independent sample t-test.RESULTS:Serum adropin was significantly correlated with maternal age, and fasting blood sugar and 2-hour blood glucose measurement after subjecting them to 75-gram Oral Glucose Tolerance Test (p-value: 0.004, 0.001, 0.001) respectively but, serum adropin was significantly negatively associated with Gestational Diabetes Mellitus (AUC: 0.927, PV=0.001, 95%CI: 0.860-0.964) the cutoff point of 38.05 with sensitivity of72.5% and specifity of 98% was considered as the most accurate point of adropin concentration for diagnosis of Gestational Diabetes Mellitus.CONCLUSION:Low level of serum adropin is independent diagnostic factor for Gestational Diabetes Mellitus. 

DOI

10.52573/ipmj.2023.182287

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