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Abstract

ABSTRACT: BACKGROUND:Globally, pancreatic cancer is the 11th most common cancer in women and the 12th most common in men. Many studies have been done to reveal the relationship and the mechanism between diabetes and pancreatic cancer. Some revealed the relationship between diabetes and increased risks of pancreatic cancer in both males and females. Another revealed that new onset diabetes could potentially indicate early stage pancreatic cancer.OBJECTIVE:To determine the association between diabetes and clinic-pathological features of pancreatic carcinoma.PATIENTS AND METHODS:A case control study conducted in Baghdad Oncology Teaching Hospital and in Al-Amal National Hospital for the treatment of cancerous tumors during a period of nine months from April till the end of December 2020. It included 66 patients referred from GIT centers or any other surgical departments and newly diagnosed as pancreatic cancer and divided into two groups: Case group included 29 patients who were a known case of type 2 diabetes for at least one year and newly diagnosed with pancreatic cancer and control group included 37 patients newly diagnosed with pancreatic cancer but had no diabetes.RESULTS:In this study, no significant difference between the study groups in regards to the mean of Ca19.9 level. Diabetes was significantly associated with increase rate of Hypertension among pancreatic cancer patients. Diabetic patients were with shorter PFS and higher incidence of progression than non-diabetic patients were.CONCLUSION:Diabetes is not only one of the causes of pancreatic cancer but also as a complication of pancreatic cancer. Diabetic patients are associated with hypertension, worse survival and diabetes can be a predictive factor in pancreatic cancer survival. 

DOI

10.52573/ipmj.2024.182849

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