Abstract
BACKGROUND: Several line of evidence have indicated the role serum thyroglobulin (Tg) concentrations in differentiating malignant from benign thyroid cancer. However, such a role in differentiating follicular from papillary thyroid carcinoma still needs more studies.OBJECTIVE: To evaluate the prognostic value of preoperative serum Tg level in differentiation between follicular and papillary thyroid cancer in patients undergoing thyroidectomy.PATIENTS AND METHODS: This is a retrospective single center study including 50 patients diagnosed with thyroid carcinoma and scheduled to have total thyroidectomy. Patients‟ demographic and final histopathology reports were obtained. Serum Tg was measure preoperative.RESULTS: Papillary thyroid carcinoma (PTC) was reported in 38 patients (76%), while the other 12 patients (24%) were found to have follicular thyroid carcinoma (FTC). The sensitivity and specificity of Tg in detection of PTC was 60.53% and 33.33%. While the sensitivity and specificity of Tg was 33.33% and 60.52% in predicating FTC. Hypocalcemia was the most common complication, up to 10%. There was no significant relationship between any of the included demographic or clinical factors and the type of cancer or the development of complications.CONCLUSION: Thyroglobulin has a moderate sensitivity for detection PTC (60.53%), while it has poor sensitivity for detection FTC (33.33%).
Recommended Citation
Hussein, Bashar and Mahdi, Qahtan
(2024)
"The Role of Thyroglobulin as Predictive Biomarker for Diagnosis of Differentiated Thyroid Cancer in Al- Imammein Al- Kadhumain Medical City,"
Iraqi Postgraduate Medical Journal: Vol. 23:
Iss.
2, Article 10.
DOI: 10.52573/ipmj.2024.183818
Available at:
https://ipmj.researchcommons.org/journal/vol23/iss2/10
DOI
10.52573/ipmj.2024.183818