Abstract
ABSTRACT: BACKGROUND: lupus nephritis is a fatal complication of systemic lupus erythematosus (SLE), the serological hallmark of SLE is the presence of circulating autoantibodies directed against a wide variety of nuclear, cytoplasmic and plasma membrane antigens among which are anticardiolipin (ACL),anti-B2glycoprotein and anti-C1q antibodies, together with the consumption of complement component (C3 &C4) by immune complex mediated reaction. AIM OF STUDY: To shed light on the relations among these autoantibodies and with complement component in lupus nephritis patients. METHODS: Tthe study was conducted on 25 patients with lupus nephritis, attended the renal clinic in specialized surgical hospital/ medical city /Baghdad, 25 lupus patients without nephritia and 25 healthy controls. Enzyme linked immunsorbant assay was used for detection for ACL, anti-B2GP, anti-C1q, while single radial immundiffusion plates used for the estimation of C3& C4. RESULTS AND CONCLUSION: Anticardiolipin antibodies correlated significantly with anti-B2GP IgG & IgM (P
Recommended Citation
Noor, Nawar Abass Abud; Al-Shemari, Kholod Daher Habib; Sersam, Lilyan W.; Auda, Ibtesam Ghadhban; Tae, Nada Khadum Al-; and Al-Kaisi, Aroub Abdul Rahman
(2007)
"Evidence of Correlation between Some Auto Antibodies with Complement Component in Lupus Nephritis,"
Iraqi Postgraduate Medical Journal: Vol. 6:
Iss.
1, Article 11.
Available at:
https://ipmj.researchcommons.org/journal/vol6/iss1/11