Cyclophosphamide and Doxorubicin but Not Methotrexate Responsible For Rapid Development of the Resistance to Ciprofloxacin in Uropathogenic Escherichia Coli in Vitro

Authors

• Ibtesam Ghadhban Auda

Abstract

ABSTRACT: BACKGROUND: The effect of anticancer chemotherapies on mammalian cells had been studied previously but few studies are performed to study the reaction of the bacterial cell toward mutagenic chemotherapies. We sought to study the effect of some anticancer chemotherapies on the rapid development of resistance to ciprofloxacin in ciprofloxacin susceptible uropathogenic E.coli (UPEC) in vitro. METHODS: Two methods of mutation induction are performed, modified Ames test and modified tube method. Cyclophosphamide, doxorubicin and methotrexate (MTX) at plasma concentration tested as mutagenic drugs towards ciprofloxacin resistance in UPEC. Disc diffusion test for antibiotic susceptablity is also used. Chi-square test test and pooled t test are used for statistical analysis. RESULTS: - Antibiotic susceptibility test; Multidrug resistance (70%) was found in the UPEC isolates and is often associated with the isolates of leukemic patients (P

Recommended Citation

Auda, Ibtesam Ghadhban (2007) "Cyclophosphamide and Doxorubicin but Not Methotrexate Responsible For Rapid Development of the Resistance to Ciprofloxacin in Uropathogenic Escherichia Coli in Vitro," Iraqi Postgraduate Medical Journal: Vol. 6: Iss. 1, Article 14.
Available at: https://ipmj.researchcommons.org/journal/vol6/iss1/14