Abstract
ABSTRACT: BACKGROUND: Despite the advances in treatment of acute lymphoblastic leukemia(ALL), CNS relapse remains an obstacle to successful treatment. This study was performed to determine the frequency of CNS relapse in ALL patients and to study risk factors and outcome after CNS relapse. PATIENTS AND METHODS: A retrospective study done on 364 patients diagnosed as ALL in Central Teaching Hospital for Children-Baghdad for the period from 1st Jan 2000 to 31st Mar 2005. ALL patients whom diagnosed after 1st Jan 2004 received CTHC 2004 protocol .The following parameters were studied: gender, age, hepatomegaly, splenomegaly, LAP, mediastinal mass, initial WBC count, platelets count, FAB morphology, initial CNS involvement and if the patient received radiotherapy. RESULTS: 35 patients were excluded from the study. Out of 329 eligible patients, 76 patients (23.1%) had CNS relapse(isolated or combined), with mean duration before CNS relapse 12.30±8.28 months and median of 11 months. The following factors were significantly associated with development of CNS relapse: male gender, age
Recommended Citation
Al-Shujairi, Tariq Abadi
(2008)
"Central Nervous System Relapse in acute Lymphoblastic Leukemia: Prognostic Factors and the Outcome,"
Iraqi Postgraduate Medical Journal: Vol. 7:
Iss.
4, Article 11.
Available at:
https://ipmj.researchcommons.org/journal/vol7/iss4/11