Abstract
ABSTRACT: BACKGROUND: Hydatid disease is a widely distributed disease caused by the larval stage of the Cestode Echinococcus. Inflammation increases the synthesis of immunoglobulins and complement components (C3 and C4) presumably through the action of interleukin 1& gamma interferon. OBJECTIVE: Assessment of immunopathotogical response of scrum immnnoglobulins and complement components fC3 and C4)in Iraqi patients that might be a fleeted as inflammatory response to hydatid disease. SUBJECT AND METHOD: A total number of 50 patients with radiological diagnosis of HD wore studied. Surgical interference had been done to 20 out of 50 patients and the results of surgery gave a clinical confirmation of the diagnosis of HD. Sera from patients with HD and 38 apparently healthy controls were obtained for measurement of immunoglobulins (lgG. IgM and IgA) and complement components (C3 and C4) by Radial Immunodiffuision Assay ( Biomaghreb). RESULTS AND DISCUSSION: Hydatid patients showed increases of IgG (P value < 0.001) IgM and IgA levels (p value 0.05). This might mean consumption of complement and it's activation or it might be due to anticomplementary action of the hydatid cyst. CONCLUSION: The picture that has emerged from this study is that HC wall might have anticomplementary action. And serum complement component tend to increase in postoperative period.
Recommended Citation
Al-Awadi, ad F.
(2008)
"Assessment of Immunopathological Response of Serum Immunoglobulins and Protective Role of Complement Components in Iraqi Patients with Hydatidosis,"
Iraqi Postgraduate Medical Journal: Vol. 7:
Iss.
4, Article 8.
Available at:
https://ipmj.researchcommons.org/journal/vol7/iss4/8